Synthesis of N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging |
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| Authors: | Xiaolei Wang Miho Emoto Atsushi Sugimoto Yusuke Miyake Kaori Itto Mitsuo Amasaka Shu Xu Hiroshi Hirata Hirotada Fujii Hirokazu Arimoto |
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| Institution: | 1. Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan;2. Department of Arts and Sciences, Center for Medical Education, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo 060-8556, Japan;3. Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, North 14, West 9, Kita-ku, Sapporo 060-0814, Japan |
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| Abstract: | A scalable synthetic route for 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide (15N-TEEPONE) is described. This 15N-labeled nitroxide is suitable for electron paramagnetic resonance imaging of brain, and its higher sensitivity compared with that of its 14N-counterpart is an important advantage of the labeled derivative. |
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| Keywords: | Nitroxide radical EPR imaging Synthesis 15N-labeling |
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