Ugi three-component coupling reaction for the synthesis of 2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazocin-5(6H)-yl)-2-phenylacetamide derivatives |
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| Authors: | P Lakshmi Reddy D Ashok Kumar M Lakshmi Devi T Veera Reddy BV Subba Reddy R Narender |
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| Institution: | 1. Crop Protection Chemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India;2. Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India;3. Department of Chemistry, Vikrama Simhapuri University, Nellore 524001, Andhra Pradesh, India |
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| Abstract: | A three-component, four center Ugi reaction of 3-(1-(2-aminophenyl)-5-phenyl-1H-pyrrol-2-yl)propanoic acid with aromatic aldehyde and t-butyl isocyanide has been achieved to produce a novel class of N-tert-butyl-2-(6-oxo-11-phenyl-7,8-dihydrobenzob]pyrrolo1,2-d]1,4]diazacine-5(6H)-yl)-2-phenylacetamides in moderate to good yields. |
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| Keywords: | Claisen&ndash Schmidt reaction Paal&ndash Knorr reaction Ugi 4C-3CC reaction Benzo[b]pyrrolodiazocinyl derivatives |
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