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New chiral biscarboline N,N′-dioxide derivatives as catalyst in enantioselective reduction of ketoimines with trichlorosilane |
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| Authors: | Yu-Ning Pei Yu Deng Jing-Liang Li Li Liu Hua-Jie Zhu |
| Institution: | 1. Chinese Centre for Chirality, The Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Ministry of Education, College of Pharmacy Sciences of Hebei University, Baoding, Hebei 071002, PR China;2. State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, CAS, Kunming, Yunnan 650204, PR China |
| Abstract: | New axial N,N′-dioxide secondary amide derived from l-tryptophan was synthesized and firstly employed in catalytic enantioselective reduction of ketoimines with trichlorosilane. It was found that 4f was an effective catalyst with excellent reactivity and good enantioselectivity. Possible mechanism for the catalytic procedure was tentatively proposed. |
| Keywords: | Biscarboline N&ndash O amides Enantioselective reduction Ketoimines Trichlorosilane |
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