Boric acid in aqueous micellar medium: an effective and recyclable catalytic system for the synthesis of aryl-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitriles |
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Authors: | Mandavi Singh Shahin FatmaPreyas Ankit Shyam Babu SinghJagdamba Singh |
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Institution: | Department of Chemistry, University of Allahabad, Allahabad 211002, India |
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Abstract: | A simple, green, and efficient protocol is reported for the preparation of aryl-7,8-dihydro1,2,4]triazolo4,3-a]-pyrimidine-6-carbonitriles through one-pot multi component reaction using substituted aromatic aldehydes, malononitrile, and 3-amino1,2,4]triazole. The reaction is catalyzed by boric acid in aqueous micellar condition. Present protocol incorporates environmentally non-hazardous reaction condition, easy work-up, and use of recyclable catalytic system with associated benefits like excellent yield (84–96%) and shorter reaction time (20 min). Proposed methodology offers rapid access to substituted aryl-7,8-dihydro1,2,4]triazolo4,3-a]pyrimidine-6-carbonitriles with high atom-economy and catalytic efficiency. |
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Keywords: | Triazolopyrimidine Boric Acid Aqueous micellar medium atom economy |
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