One-pot synthesis of 1,2,4,5-tetrahydro-2,4-dioxobenzo[b][1,4]diazepine and malonamide derivatives using multi-component reactions |
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Authors: | Abbas Rahmati Samaneh AhmadiMahdi Ahmadi-Varzaneh |
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Institution: | Department of Chemistry, University of Isfahan, PO Box 81746-73441, Isfahan, Iran |
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Abstract: | In this work, a new series of 1,2,4,5-tetrahydro-2,4-dioxobenzob]1,4]diazepine and malonamide derivatives have been synthesized using an aromatic 1,2-diamine, Meldrum's acid, an isocyanide, and an arylidene malononitrile (or an aldehyde and malononitrile instead of an arylidene malononitrile) in CH2Cl2 at ambient temperature. Synthesis of 1,2,4,5-tetrahydro-2,4-dioxobenzob]1,4]diazepine proceeded via four- and five-component reactions; while the synthesis of malonamide derivatives was performed using five- and six-component reactions. In addition, a new series of the malonamide derivatives have been prepared using an aldehyde, malononitrile, Meldrum's acid, an isocyanide, and two molecules of 1,4-diamine via a six-component reaction. These procedures provide alternative methods to the synthesis of a new series of 1,2,4,5-tetrahydro-2,4-dioxobenzob]1,4]diazepine and malonamide derivatives. |
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Keywords: | Diazepines Malonamides Multi-component condensation reaction |
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