rac-BINAP-PdCl2 catalyzed Heck reactions of 3-formylquinolin-2-yl chlorides with methyl acrylate: synthesis of methyl 3-(3-formylquinolin-2-yl) acrylates |
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| Authors: | Neha Sharma Mrityunjaya AsthanaRitush Kumar Kalpana MishraRadhey M Singh |
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| Institution: | Department of Chemistry, Centre of Advance Studies, Banaras Hindu University, Varanasi 221005, U.P., India |
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| Abstract: | rac-BINAP-PdCl2 catalytic system catalyzed Heck reaction of 3-formylquinolin-2-yl chlorides with methyl acrylate in DMA is described to the synthesis of methyl 3-(3-formyl-quinolin-2-yl)-acrylates, in good to excellent yields. The reaction could be also extended with other activated alkenes to afford Heck products. Fused-benzene ring in heterocyclic and carbocyclic moieties was found to enhance the yields. |
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| Keywords: | Palladium rac-BINAP Heck reaction Quinoline Activated alkenes |
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