Amarusine A,a new dioxaspiro[4.4]nonane derivative with a butyrolactone ring from Pleioblastus amarus |
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| Authors: | Jia Sun Peicheng Zhang Qi Wei Hang Xun Feng Tang Yongde Yue Li Li Xuefeng Guo Rong Zhang |
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| Institution: | 1. State Forestry Administration Key Open Laboratory, International Centre for Bamboo and Rattan, Beijing 100102, PR China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China |
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| Abstract: | Amarusine A (1), a new polyketide derivative possessing an unusual dioxaspiro4.4]nonane derivative with a butyrolactone ring, was isolated from the leaves of Pleioblastus amarus. The structure and absolute stereochemistry of compound 1 were rigorously determined using UV, IR, HRESIMS, and 1D and 2D NMR techniques and by comparing experimental and calculated electronic circular dichroism (ECD) spectra. Amarusine A (1) exhibits a good antioxidant activity for scavenging the DPPH radical. A possible biosynthetic pathway was postulated. |
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| Keywords: | Amarusine A Pleioblastus amarus Biosynthetic pathway Antioxidant activity |
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