Synthesis of benzimidazo[2,1-b]benzothiazole derivatives through sequential Cu-catalyzed domino coupling and Pd-catalyzed Suzuki reaction |
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| Authors: | Jilong Gao Jiaoyan ZhuLubin Chen Yingying ShaoJiaqi Zhu Yijia HuangXiaoxia Wang Xin Lv |
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| Institution: | Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, People’s Republic of China |
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| Abstract: | A variety of benzod]benzo4,5]imidazo2,1-b]thiazoles were efficiently and conveniently synthesized from the Cu-catalyzed domino coupling of o-dihaloarenes with 2-mercaptobenzimidazoles. The reaction is also applicable to a series of multi-functional substrates, affording the halo-containing products with excellent selectivity. The brominated products can further react with arylboronic acids under Pd catalysis to furnish the aryl-substituted benzimidazo2,1-b]benzothiazole derivatives. |
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| Keywords: | Benzimidazo[2 1-b]benzothiazole Cu-catalyzed Domino Coupling Heterocycle |
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