CERTAIN SINGLET OXYGEN QUENCHERS AFFECT THE PHOTOREACTION BETWEEN 8-MOP and DNA |
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| Authors: | Franco Bordin Maria Teresa Conconi Alma Capozzi |
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| Institution: | Department of Pharmaceutical Sciences of University of Padova, Centre di Studio sulla Chimica el Farmaco e dei Prodotti Biologicamente Attivi del C.N.R., Padova, Italy |
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| Abstract: | The effect of certain chemicals known as singlet oxygen quenchers on the photoreaction between 8-MOP and DNA has been studied in vitro; sodium azide, l,4-diazabicyclo-(2,2,2)-octane, p-carotene and dimethylsolfoxide (used as a solvent) appeared to be capable of reducing significantly the 8-MOP ability to induce both monoadducts and cross-links in DNA. Therefore, these chemicals seem to be not useful in studying the singlet oxygen implication in the induction of biological effects of 8-MOP sensitization. |
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