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Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: a metabonomic approach |
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| Authors: | MA Constantinou D Benaki K Shulpis E Mikros |
| Institution: | a Laboratory of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-15771 Athens, Greece b Institute of Child Health, “Aghia Sophia” Children’s Hospital, 115 27 Athens, Greece c Bruker Analytik GmbH, Silberstreifen, D-76287 Rheinstetten, Germany d Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis Zografou, GR-15771 Athens, Greece |
| Abstract: | |
| Keywords: | Nuclear magnetic resonance (NMR) spectroscopy Principal component analysis (PCA) Inborn errors of metabolism (IEM) Blood spots Phenylketonuria (PKU) Maple syrup urine disease (MSUD) |
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