Synthesis of environmentally sensitive 2′-deoxyguanosine containing solvatochromic pyrene fluorophore |
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| Authors: | Yoshio Saito Yuta ShinoharaShinya Ishioroshi Azusa SuzukiMakiko Tanaka Isao Saito |
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| Institution: | Department of Chemical Biology and Applied Chemistry, School of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan |
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| Abstract: | The synthesis and photophysical property of novel solvatochromic pyrene derivative, Apa5 and fluorescent guanine ApaG8 were described. These newly synthesized fluorescent pyrene derivatives exhibited solvent polarity dependent fluorescence at longer wavelengths. Such environmentally sensitive pyrene derivatives can be used as a reporter probe that is sensitive to the changes in the microenvironment around DNA either in vitro or in vivo. |
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