Catalytic asymmetric Mannich-type reactions of fluorinated ketoesters with N-Boc aldimines in the presence of chiral palladium complexes |
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| Authors: | Young Ku KangDae Young Kim |
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| Affiliation: | Department of Chemistry, Soonchunhyang University, Asan, Chungnam 336-745, Republic of Korea |
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| Abstract: | ![]()
The catalytic enantioselective Mannich reaction promoted by chiral palladium complexes is described. The treatment of α-fluoro-β-ketoesters with N-Boc-aldimines under mild reaction conditions afforded the corresponding β-aminated α-fluoro-β-ketoesters with excellent enantioselectivities (up to 99% ee). |
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| Keywords: | Mannich reaction Asymmetric catalysis Chiral palladium catalysts α-Fluoro-β-ketoesters Aldimines |
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