| Al3+离子对卵磷脂聚集体结构的影响 |
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| 引用本文： | 陈呼和,张 莉,杨展澜,王 凡,翁诗甫,吴瑾光.Al3+离子对卵磷脂聚集体结构的影响[J].无机化学学报,2004,20(2):159-163. |
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| 作者姓名： | 陈呼和 张 莉 杨展澜 王 凡 翁诗甫 吴瑾光 |
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| 作者单位： | 化学生物学系,化学与分子工程学院,稀土材料化学及应用国家重点实验室,北京大学,北京,100871 |
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| 基金项目： | 国家自然科学基金资助项目(No.20171004和20023005)。 |
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| 摘 要： | 本文用浊度滴定(UV-Vis)、透射电镜(TEM)和激光光散射(QELS)等方法对Al3+离子与卵磷脂(EYPC)囊泡之间的相互作用及其这种相互作用对溶液中磷脂微结构的影响进行了研究。结果表明，一定量的Al3+离子使EYPC多层囊泡转变为线团状聚集体;Al3+与牛磺胆酸钠(TC)的协同作用可以破坏EYPC的多层囊泡结构，促进相转变，形成混合胶束。
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| 关 键 词： | 卵磷脂 牛磺胆酸钠 多层囊泡 浊度 相转变 |
| 修稿时间： | 2003年7月10日 |
Influence of Al3+ Ions on the Aggregation Structure of Egg-yolk Phosphatidylcholine |
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| CHEN Hu-He,ZHANG Li,YANG Zhan-Lan,WANG Fan,WENG Shi-Fu and WU Jin-Guang.Influence of Al3+ Ions on the Aggregation Structure of Egg-yolk Phosphatidylcholine[J].Chinese Journal of Inorganic Chemistry,2004,20(2):159-163. |
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| Authors: | CHEN Hu-He ZHANG Li YANG Zhan-Lan WANG Fan WENG Shi-Fu and WU Jin-Guang |
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| Institution: | The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871,The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871,The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871,The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871,The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 and The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 |
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| Abstract: | It is known that phosphatidylcholine (PC) multi-lamellar vesicles can solubilize efficiently cholesterol in human bile. Although the interaction of trivalent metal ions to PC bi-layer membrane has been widely studied, less attention has been given to effects of trivalent metal ions on PC vesicles, especially in the presence of bile salts. In this article, we examined the interaction of egg-yolk phosphatidylcholine (EYPC) multi-lamellar vesicles with Al3+ and sodium taurocholate TC / Al3+ mixture in aqueous solution by using UV-Vis, FTIR, QELS and TEM techniques respectively. The results of TEM observation indicate that addition of Al3+ changed EYPC multi-lamellar vesicles into random coils. The data of UV-Vis, FTIR, QELS and TEM showed that the mixture of TC and Al3+ induced a phase transition from EYPC multi-lamellar vesicles to mixed micelles through the synergy of TC with Al3+. The phase transition occurred more easily when the molar ratio of TC and Al3+ was less than 1 . But a less amount of Al3+ and TC mixture could destroy EYPC multi-lamellar vesicles and decreased the solubility of EYPC in aqueous solution. It is suggested that the synergy of TC with Al3+ will affect the capacity of PC multi-lamellar vesicles to solubilize cholesterol in human bile. |
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| Keywords: | phosphatidylcholine sodium taurocholate multi-lamellar vesicles turbidity phase transition |
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