A Journey to the Total Synthesis of Daptomycin |
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| Authors: | Hiu Yung Lam Rannveig Ingebrigtsen Gaarden Xuechen Li |
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| Institution: | 1. Department of Chemistry, The University of Hong Kong, , Hong Kong SAR, P. R. China;2. Department of Chemistry, The University of Edinburgh, , Edinburgh, UK |
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| Abstract: | Daptomycin, the first antibiotic of its class, provides a new structural motif for the development of new antibiotics. Recently, we have completed the total synthesis of daptomycin. The development of the successful synthetic strategy is described here, including the application of serine/threonine ligation mediated peptide cyclization to the daptomycin macrocyclization. |
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| Keywords: | antibiotics cyclization daptomycin peptides total synthesis |
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