| 影响喹诺酮C—4位构效关系的若干因素 |
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| 引用本文： | 李江波,林瑞森.影响喹诺酮C—4位构效关系的若干因素[J].化学研究与应用,1999,11(3):279-281. |
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| 作者姓名： | 李江波 林瑞森 |
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| 作者单位： | 浙江大学化学系 |
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| 摘 要： | 喹诺酮类药物是两类重要抗生素之一，此类化合物的结构见图１。虽然喹诺酮不同位置的结构修饰已涌现出许多广谱、高效、低毒性的化疗药物，如诺氟沙星、环丙沙星、氧氟沙星等［１］。但对Ｃ－４位的修饰却未能成功：Ｃ－４位酮基被硫酮基、亚胺基取代均使活性消失［２］；...
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| 关 键 词： | 喹诺酮 构效关系 分子力学 AM1 |
SOME FACTORS INFLUENCING ON THE STRUCTUREACTIVITY RELATIONSHIP OF C4 POSITIN OF QUINOLONE |
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| Li JiangboLin RuisenYu Qingsen.SOME FACTORS INFLUENCING ON THE STRUCTUREACTIVITY RELATIONSHIP OF C4 POSITIN OF QUINOLONE[J].Chemical Research and Application,1999,11(3):279-281. |
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| Authors: | Li JiangboLin RuisenYu Qingsen |
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| Abstract: | In this paper,the structure-activity relationship of c-4 position of quinolone and its analogues was sdudied by MM and AM1.The results showed that the coplanarity of the parent nucleus,the coplanarity between the group of c-4 position and the parent mucleus,the coplanarity between carboxy1 and keto group are all very important to biologcal activities. |
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| Keywords: | guinolone structure-activity relationship MM AM1 |
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