A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates |
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| Authors: | Wu Weidong Freel Meyers Caren L Borch Richard F |
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| Affiliation: | Department of Medicinal Chemistry and Molecular Pharmacology and Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA. |
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| Abstract: | ![]()
[reaction: see text] A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate. |
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