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| 以上转换纳米颗粒和光动力疗法为基础的肿瘤联合治疗研究进展 | |
| 引用本文： | 陈雨濛,姜国玉,王雪松. 以上转换纳米颗粒和光动力疗法为基础的肿瘤联合治疗研究进展[J]. 影像科学与光化学, 2016, 34(4): 297-311. DOI: 10.7517/j.issn.1674-0475.2016.04.297 |
| 作者姓名： | 陈雨濛 姜国玉 王雪松 |
| 作者单位： | 中国科学院 理化技术研究所 光化学转换与功能材料重点实验室, 北京 100190 |
| 基金项目： | 国家自然科学基金委员会基金项目(21301182) |
| 摘 要： | 光动力疗法作为一种非侵入性治疗手段已广泛应用于肿瘤的临床治疗。然而其疗效却深受紫外-可见光组织穿透深度的限制。镧系掺杂上转换纳米颗粒可以将近红外光转换为紫外-可见光,被广泛用于与传统光敏剂结合实现更为高效的光动力治疗。近年来,以上转换纳米颗粒和光动力疗法为基础的肿瘤联合治疗研究备受关注,本文重点介绍了该领域的最新研究进展,并对其未来发展方向作出了展望。 |
| 关 键 词： | 光动力疗法 上转换纳米颗粒 联合疗法 |
| 收稿时间： | 2016-03-30 |
Advances of Cancer Combination Therapy Based on Upconversion Nanoparticles and Photodynamic Therapy |
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| CHEN Yumeng,JIANG Guoyu,WANG Xuesong. Advances of Cancer Combination Therapy Based on Upconversion Nanoparticles and Photodynamic Therapy[J]. Imaging Science and Photochemistry, 2016, 34(4): 297-311. DOI: 10.7517/j.issn.1674-0475.2016.04.297 | |
| Authors: | CHEN Yumeng JIANG Guoyu WANG Xuesong |
| Affiliation: | Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R,China |
| Abstract: | Photodynamic therapy(PDT), a non-invasive treatment modality, has been widely used clinicallyagainst many types of cancers. However, its efficacy is heavily limited by the low tissue penetration depth of the UV-visible irradiation. Lanthanide-doped upconversion nanoparticles (UCNPs), which can convert near-infrared light to UV-visible light, have been used successfully to improve PDT activities of traditional photosensitizers. Recently, the combination therapy based on UCNPs-PDT is drawing increasing attention, and the related advances as well as perspectives have been presented in this review. |
| Keywords: | photodynamic therapy upconversion nanoparticles combination therapy |
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