Calcium signals can freely cross the nuclear envelope in hippocampal neurons: somatic calcium increases generate nuclear calcium transients |
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Authors: | Anja Eder Hilmar Bading |
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Institution: | (1) Department of Neurobiology, Interdisciplinary Centre for Neurosciences, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany |
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Abstract: | Background In hippocampal neurons, nuclear calcium signaling is important for learning- and neuronal survival-associated gene expression.
However, it is unknown whether calcium signals generated by neuronal activity at the cell membrane and propagated to the soma
can unrestrictedly cross the nuclear envelope to invade the nucleus. The nuclear envelope, which allows ion transit via the
nuclear pore complex, may represent a barrier for calcium and has been suggested to insulate the nucleus from activity-induced
cytoplasmic calcium transients in some cell types. |
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Keywords: | |
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