| 聚(酪氨酸酯对苯二甲酰胺)碳酸酯药物控制释放材料的研究 |
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| 引用本文： | 卓仁禧,胡斌.聚(酪氨酸酯对苯二甲酰胺)碳酸酯药物控制释放材料的研究[J].高分子学报,1997(3):295-299. |
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| 作者姓名： | 卓仁禧 胡斌 |
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| 作者单位： | 武汉大学化学系国家教委生物医用高分子材料开放实验室 |
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| 摘 要： | 报道了一类生物可降解聚（酪氨酸酯对苯二甲酰胺）碳酸酯的合成和结构表征，研究了聚合物的性质和体外降解性能，并以５ 氟脲嘧啶和牛血清白蛋为模型，对它们作为药物控制释放材料的性能进行了初步评价．
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| 关 键 词： | 聚（酪氨酸酯对苯二甲酰胺）碳酸酯，控制释放，生物可降解材料，5 氟脲嘧啶，牛血清白蛋白 |
STUDIES ON POLY(TEREPHTHALYL TYROSINE ESTER AMIDE) CARBONATES DRUG CONTROLLED RELEASE MATERIALS |
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| ZHUO Renxi,HU Bin,FAN Changlie.STUDIES ON POLY(TEREPHTHALYL TYROSINE ESTER AMIDE) CARBONATES DRUG CONTROLLED RELEASE MATERIALS[J].Acta Polymerica Sinica,1997(3):295-299. |
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| Authors: | ZHUO Renxi HU Bin FAN Changlie |
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| Abstract: | New biodegradable Poly(terephthalyl tyrosine ester amide)carbonates were synthesized from tyrosine derived diphenols and phosgene in dichloromethane using pyridine as acid acceptor.Their chemical structures were confirmed by 1H NMR,FT IR and elemental analysis.The physical properties of the polycarbonates could be modulated by the use of different tyrosine esters.The in vitro degradation and drug release profile of 5 fluorouracil and bovine serum albumin were also studied. |
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| Keywords: | Poly(terephthaly tyrosine ester Amide)carbonates Controlled release Biodegradable materials 5 Fluorouracil Bovine serum albumin |
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