七配位二聚体配合物{(PhCH2)2Sn·[2,6-(O2C)2C5H3N](CH3OH)}2的合成及结构

在三乙胺存在下利用三苄基氯化锡和2,6-吡啶二甲酸,以1:1摩尔比反应,合成了七配位二聚体{(PhCH2)2Sn[2,6-(O2C)2C5H3N](CH3OH)}2.通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征.用X射线单晶衍射法测定了该化合物的晶体结构.化合物为三斜晶系,P1空间群,晶胞参数a=0.9625(6)nm,b=1.0947(9)nm,c=1.996(3)nm,α=90.00(2)°,β=87.69(3)°,γ=90.00(3)°,Z=2,V=2.102(6)nm3,μ=1.248mm-1,F(000)=1000,R1=0.0476,wR2=0.0782.化合物中2个锡原子呈七配位畸变五角双锥构型.生物活性测试结果表明,该化合物具有较强的体外抗肿瘤活性.

Synthesis and Structure of Seven-coordinate Dimer {(PhCH2)2Sn[2,6-(O2C)2C5H3N](CH3OH)}2

A novel seven-coordinate dimer {(PhCH2)2Sn[2,6-(O2C)2C 5H3N](CH3OH)}2 was synthesized by the reaction of(PhCH2)3SnCl with 2,6-pyridine dicarboxylic acid in 1:1 molar ratio in methanol with Et3N. The structure of the dimmer was characterized by elemental analysis, IR, 1H NMR, and X-ray single crystal diffraction. The crystal belongs to a triclinic system with space group P1, a=0.962 5(6) nm, b=1.094 7(9) nm, c=1.996(3) nm, α=90.00(2)°, β=87.69(3)°, γ=90.00(3)°, Z=2, V=2.102(6) nm3, μ=1.248 mm-1, F(000)=1 000, R1=0.047 6, wR2= 0.078 2. In the crystals of complex, the tin atoms rendered seven-coordinate in a distorted pengonal bipyramidal structure. The complex was tested in vitro against human tumour cell lines, MCF-7 and WiDr, and displayed a higher activity.