Predicting the selectivity of imprinted polymers |
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Authors: | M J Whitcombe L Martin E N Vulfson |
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Institution: | (1) Macromolecular Sciences Department, Institute of Food Research, Earley Gate, Whiteknights Road, RG6 6BZ Reading, UK |
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Abstract: | Summary Imprinted polymers as stationary phases for HPLC separations have been the subject of extensive investigations in recent years.
In order to aid the rational design of synthetic protocols for the preparation of imprinted polymers, a series of calculations
were made to assess the equilibrium concentration of templatemonomer complexes as a function of association constant (K) for the functional groups involved in the interactions and initial concentrations of reactants. This data was then used
to predict the selectivity of polymers prepared under different reaction conditions and the model was tested using an experimentally
determined value ofK and separation factors taken from the literature. |
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Keywords: | Column liquid chromatography Imprinted polymer Non-covalent imprinting Selectivity and capacity Association constant |
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