Synthesis and reduction of 5-halo-and 5-nitro-1-(benzofuran-3-yl)-2-phenylethanones |
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Authors: | H Kwiecien M Szychowska |
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Institution: | (1) Department of Organic Synthesis and Drug Technology, Szczecin University of Technology, 71-065 Szczecin, Poland |
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Abstract: | Novel 1-(2-alkylbenzofuran-3-yl)-2-(4-methoxyphenyl)ethanones having a halogen or nitro group in position 5 of the benzofuran
ring were synthesized starting with the corresponding 2-(2-formylphenoxy)alkanoic acids. 1-(2-Alkylbenzofuran-3-yl)-2-phenylethanols
containing bromine or chlorine atom were prepared in high yields by reduction of the corresponding ethanones with lithium
aluminum hydride. Selective catalytic reduction of nitro 1-(2-alkylbenzofuran-3-yl)-2-(4-methoxyphenyl)ethanones to the corresponding
amino compounds under Pd/C in room temperature was achieved.
Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1158–1166, August, 2006. |
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Keywords: | amines benzofurans ethanols ethanones acylation reduction |
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