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Design and Synthesis of Matrix Metalloprotease Photoaffinity Trimodular Probes |
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| Authors: | QIU Wenwei XU Jie LI Xin ZHONG Li LI Jingya LI Jia NAN Fajun |
| Institution: | 1. Chinese National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;2. Department of Chemistry and Institute of Medicinal Chemistry, East China Normal University, Shanghai 200062, China;3. Tel./Fax: 0086‐021‐50800954 or 0086‐021‐50801552 |
| Abstract: | To explore the molecular mechanism of the matrix metalloproteinases (MMPs) in tumor processes, two photoaffinity trimodular probes were designed and synthesized based on the structure activity relationship and the following photoaffinity labelling experiments afforded positive results. |
| Keywords: | trimodular probe photoaffinity labeling protein profiling click chemistry matrix metalloprotease |
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