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Copper-mediated N- and O-arylations with arylboronic acids in a continuous flow microreactor: a new avenue for efficient scalability |
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| Authors: | Brajendra K. Singh Christian V. Stevens Davy R.J. Acke Erik V. Van der Eycken |
| Affiliation: | a Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Heverlee, Leuven, Belgium b Research group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Gent, Belgium c Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India |
| Abstract: | A continuous flow procedure has been elaborated for the copper(II)-mediated N- and O-arylation of a range of compounds with arylboronic acids using a commercial microreactor setup. The compounds could be continuously generated in good yields paving the way for efficient scalability. |
| Keywords: | Copper-mediated N-Arylation O-Arylation Arylboronic acid Continuous flow Microreactor Scalability |
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