溴化镁催化的1,2,3,4-四氢吡啶酮无溶剂合成研究

An efficient and environmentally friendly procedure for the one-pot synthesis of tetrahydropyrimidinones from aldehydes, β-diketones and urea/thiourea by using magnesium bromide as an inexpensive and easily available catalyst under solvent-free conditions was described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields (74%-94%) and short reaction time (45-90 min). The structure of the Biginelli reaction product from β-diketone, salicylaldehyde and urea has been proposed to possess an oxygen-bridge by cyclization (intramolecular Michael-addition).

Efficient Magnesium Bromide‐Catalyzed One‐pot Synthesis of Substituted 1,2,3,4‐Tetrahydropyrimidin‐2‐ones Under Solvent‐free Conditions

An efficient and environmentally friendly procedure for the one‐pot synthesis of tetrahydropyrimidinones from aldehydes, β‐diketones and urea/thiourea by using magnesium bromide as an inexpensive and easily available catalyst under solvent‐free conditions was described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields (74%–94%) and short reaction time (45–90 min). The structure of the Biginelli reaction product from β‐diketone, salicylaldehyde and urea has been proposed to possess an oxygen‐bridge by cyclization (intramolecular Michael‐addition).