Synthesis of a 4H-anthra[1,2-b]pyran derivative and its antimicrobial activity |
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Authors: | Hussain Hidayat Aziz Shahid Schulz Barbara Krohn Karsten |
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Institution: | Department of Chemistry, Universit?t Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany. Hidayat110@gmail.com |
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Abstract: | The five-step synthesis of the new 4H-anthra1,2-b]pyran derivative 1 is reported. The key steps in this approach included a Marschalk alkylation of 1,4-dihydroxyanthraquinone followed by a Baker-Venkataraman reaction and then an acid-catalyzed cyclization of ring A to form the 4H-anthra1,2-b]pyran system. Two compounds, the 4H-anthra1,2-b]pyran 1 and the anthraquinone derivative 6 were evaluated for antimicrobial activity and showed moderate antialgal, antifungal, and antibacterial activities. |
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