Aloeverasides A and B: Two Bioactive C‐Glucosyl Chromones from Aloe vera Resin |
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| Authors: | Najeeb Ur Rehman Hidayat Hussain Mohammed Khiat Samia Ahmed Al‐Riyami René Csuk Husain Yar Khan Ghulam Abbas Ghanim Salim Al‐Thani Ivan R. Green Ahmed Al‐Harrasi |
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| Affiliation: | 1. UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, Nizwa, Sultanate of Oman;2. +96825446328;3. Martin‐Luther Universit?t Halle‐Wittenberg, Halle;4. Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al Mauz, Nizwa, Sultanate of Oman;5. DARIS Centre for Scientific Research and Technology Development, University of Nizwa, Birkat Al Mauz, Nizwa, Sultanate of Oman;6. Department of Chemistry and Polymer Science, University of Stellenbosch, South Africa |
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| Abstract: | Two new C‐glucosyl chromones named aloeverasides A ( 1 ) and B ( 2 ) were isolated from the resin of Aloe vera (L.) Burm.f . The structures of the two new natural products were elucidated based on 1D‐ (1H‐ and 13C‐NMR) and 2D‐NMR (COSY, HSQC, and HMBC) spectroscopic techniques and mass spectrometry (ESI‐MS). Aloeverasides A ( 1 ) and B ( 2 ) were evaluated for their anticancer activity, and both induced a 76.4 and 70.5% growth inhibition of the breast cancer cell line (MDA‐MB‐231) at a concentration of 100 μm . Both compounds were also evaluated for their 1,1‐diphenyl‐2‐picryl‐hydrazyl antioxidant, urease enzyme, and α‐glucosidase enzyme inhibition activities. Aloeverasides A ( 1 ) and B ( 2 ) displayed good urease enzyme inhibition activities (62 and 55%, resp.), as well as antioxidant activity in which aloeveraside A ( 1 ) had a value of 60% inhibition, while aloeveraside B ( 2 ) demonstrated a more potent antioxidant activity with 80% inhibition. |
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| Keywords: | Aloe vera (L.) Burm.f. Natural products Chromones Structure elucidation |
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