Isocassiaoccidentalin B,A New C‐Glycosyl Flavone Containing a 3‐Keto Sugar,and Other Constituents from Cassia nomame |
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| Authors: | Ahmed Shah Syed Muhammad Akram Ok‐Nam Bae Chul Young Kim |
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| Institution: | 1. Institute of Pharmaceutical Science and Technology, College of Pharmacy, Hanyang University, Ansan, Korea;2. + 82‐31‐4005809+82‐31‐4005859 |
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| Abstract: | A new C‐glycosyl flavone containing a 3‐keto sugar, isocassiaoccidentalin B ( 1 ), was isolated from whole Cassia nomame (Sieber ) Honda plants, along with eleven known compounds, including two flavonoids ( 2 and 3 ), five flavonoid glycosides ( 4 – 8 ), two chalcones ( 9 and 10 ), and two phenylpropanoids ( 11 and 12 ). The chemical structures of all compounds were determined via 1D‐ and 2D‐NMR, and ESI‐MS. Among these, compounds 2 , 3 , 7 , and 8 were found to be the most potent in inhibiting nitric oxide release. Compounds 1 , 2 , 4 , 8 , 9 , and 10 showed significant free‐radical scavenging activity. |
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| Keywords: | Cassia nomame Flavone C‐glycosides Isocassiaoccidentalin B Nitric oxide production Anti‐inflammatory activities |
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