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Prototype of immunochromatographic assay strips using colloidal CdTe nanocrystals as biological luminescent label |
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| Authors: | Li Jun Zhao Kui Hong Xia Yuan Hang Ma Lan Li Jinghong Bai Yubai Li Tiejin |
| Institution: | aCollege of Chemistry, Jinlin University, Changchun 130023, PR China bKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, PR China cKunming Yunda Monoclonal Antibody Technology Center, Yunan University, Kunming 650091, PR China |
| Abstract: | Colloidal semiconductor nanocrystals have attracted considerable attention as a novel biological luminescent label. The bioinorganic conjugates of luminescent CdTe nanocrystals and protein, including CdTe/BSA (bovine serum albumin) and CdTe/MAB (mouse monoclonal antibody against hepatities B surface antigen), were formed via electrostatic/coordination self-assembly. Pure CdTe nanocrystals, CdTe/BSA and CdTe/MAB were used in the immunochromatographic assay experiments, respectively. And the results indicated that CdTe nanocrystals could be used and developed as a novel label with good stability, high sensitivity and facile determination of several analytes in immunochromatographic assay strips. |
| Keywords: | CdTe BSA MAB Self-assembly Immunochromatographic assay |
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