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The CeCl3·7H2O-NaI system as promoter in the synthesis of functionalized trisubstituted alkenes via Knoevenagel condensation |
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| Authors: | Giuseppe Bartoli Sandra Giuli Enrico Marcantoni Massimo Massaccesi |
| Institution: | a Dipartimento di Chimica Organica ‘A. Mangini’, Università di Bologna, viale Risorgimento 4, I-40136 Bologna, Italy b Dipartimento di Scienze degli Alimenti, Università di Foggia, via Napoli 25, I-71100 Foggia, Italy c Dipartimento di Scienze chimiche, Università di Camerino, via S. Agostino 1, I-62032 Camerino, MC, Italy |
| Abstract: | The arylidene malonates with two different geminal carboxylate functions, a suitable class of substrates of several synthetic and pharmacological studies, are easily available through Knoevenagel condensation of ethyl tert-butyl malonate and different aromatic aldehydes. The results have increased the potentialities of CeCl3·7H2O-NaI system as a type of water-tolerant green Lewis acid promoter for carbon-carbon bond forming procedures. |
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