Modification of guanine residues in PNA-synthesis by PyBOP |
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| Authors: | Stephan Pritz Yvonne Wolf Clementine Klemm Michael Bienert |
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| Affiliation: | Leibniz-Institute of Molecular Pharmacology, Robert-Rössle-Strasse 10, 13125 Berlin, Germany |
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| Abstract: | ![]()
The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O4-phosphonium compounds of the nucleobase guanine which can be converted into C4-modified guanine-derived PNAs by nucleophiles. |
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| Keywords: | Coupling reagents PNA synthesis Guanine PyBOP HATU |
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