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Trichiol and 3-epitrichiol acetate, novel cytotoxic sterols with an unprecedented 2,6-dioxabicyclo[2.2.2]octan-3-one ring system from the myxomycete Trichia favoginea var. persimilis |
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| Authors: | Kouken Kaniwa Tomomi Sonoda Masahiko Hayashi Masami Ishibashi |
| Institution: | a Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan b Ohtsu-ko, Kochi 781-5102, Japan c The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan |
| Abstract: | Trichiol (1) and 3-epitrichiol acetate (2), two new sterols, have been isolated from field-collected fruit bodies of the myxomycete, Trichia favoginea var. persimilis, and their structures elucidated by spectral data. Trichiol (1) and 3-epitrichiol acetate (2) possess an unprecedented 2,6-dioxabicyclo2.2.2]octan-3-one ring system. Trichiol (1) was cytotoxic against HeLa cells, while compound 2 proved to exhibit reversal effect against TNF-related apoptosis inducing ligand (TRAIL)-resistant Jurkat cell lines. |
| Keywords: | Myxomycete Trichia favoginea var persimilis Fruit body 2 6-dioxabicyclo[2 2 2]octan-3-one ring Cytotoxicity |
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