A highly chemoselective Boc protection of amines using sulfonic-acid-functionalized silica as an efficient heterogeneous recyclable catalyst |
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| Authors: | Biswanath Das Katta Venkateswarlu Maddeboina Krishnaiah Harish Holla |
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| Institution: | Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A facile and versatile method for the chemoselective Boc protection of amines has been developed by a treatment with (Boc)2O in the presence of sulfonic-acid-functionalized silica as a catalyst. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines; aminols, amino-esters; and sulfonamides. The catalyst works under heterogeneous conditions and can be recycled. |
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| Keywords: | Amine Boc protection (Boc)2O Sulfonic-acid-functionalized silica Heterogeneous recyclable catalyst |
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