New synthesis of cis-3,4-diaryl-1-tosylpyrrolidines |
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| Authors: | Meng-Yang Chang Chun-Li Pai |
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| Institution: | a Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung 811, Taiwan
b Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan |
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| Abstract: | Unsymmetrically substituted cis-3,4-diarylpyrrolidines are synthesized in nearly 25% overall yields starting from 4-aryl-1,2,5,6-tetrahydropyridines by iterative reactions using the combination of m-chloroperoxybenzoic acid (MCPBA) and boron trifluoride etherate (BF3·OEt2) followed by Grignard addition, elimination and hydrogenation sequence. |
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| Keywords: | 4-Aryl-1 2 5 6-tetrahydropyridines 3-Arylpyrrolines cis-3 4-Diarylpyrrolidines Grignard addition m-Chloroperoxybenzoic acid Boron trifluoride etherate |
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