Asymmetric induction in the reactions of 3-aryl-1,2,4-triazin-5(4H)-ones with C-nucleophiles |
| |
| Authors: | Ilya N Egorov Grigory V Zyryanov Vladimir L Rusinov |
| |
| Institution: | a Department of Organic Chemistry, Urals State Technical University, 19, Mira St., Ekaterinburg 620002, Russian Federation
b Institute of Organic Synthesis of RAS (Urals Division), 20, S. Kovalevskaya St., Ekaterinburg 620219, Russian Federation |
| |
| Abstract: | 3-Aryl-1,2,4-triazin-5(4H)-ones, in the presence of N-protected amino acids, react with C-nucleophiles to form 1-acyl-6-Nu-3-aryl-1,6-dihydro-1,2,4-triazin-5(4H)-ones in high diastereomeric excess. This is the first case of the use of amino acids as chiral auxiliaries in nucleophilic additions to triazinones. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
