Synthesis of arginine-containing hydroxamate dipeptidomimetics |
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| Authors: | Jiwon Seo |
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| Institution: | Department of Chemistry, Department of Biochemistry, Molecular Biology, and Cell Biology, The Center for Drug Discovery and Chemical Biology, Northwestern University, Evanston, IL 60208-3113, USA |
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| Abstract: | The syntheses of arginine-containing hydroxamates using various peptide coupling methods are described. Fmoc-Arg(NO2)-Cl prepared at low temperature did not undergo intramolecular δ-lactam formation and effectively provided desired hydroxamates (8 and 10) in good yields. Fmoc and N-nitro protecting groups can be easily removed. Therefore, this report provides a facile synthesis of arginine-containing peptidomimetic compounds. |
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| Keywords: | Arginine Hydroxamate Peptidomimetics Acid chloride |
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