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A new application of the Mitsunobu reaction in the synthesis of phosphonium salts |
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| Authors: | Roman Mazurkiewicz Tadeusz Gorewoda Anna Ku?nik Miros?awa Grymel |
| Affiliation: | Department of Organic and Bioorganic Chemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, PL 44-100 Gliwice, Poland |
| Abstract: | The condensation of methanol or primary alcohols with triphenylphosphonium tetrafluoroborate in the presence of ethyl azodicarboxylate and triphenylphosphine in THF at room temperature gives the respective alkyltriphenylphosphonium salts in good yields. The reaction also worked for the conversion of N-acyl-2-hydroxyglycinates into N-acyl-2-triphenylphosphonioglycinates. |
| Keywords: | Mitsunobu reaction Phosphines P-alkylation Alkyltriphenylphosphonium salts N-acyl-2-triphenylphosphonioglycinates |
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