A synthesis of pyrrolo[2,1-a]isoquinolines through the reaction of activated acetylenes and isoquinoline in the presence of ethyl bromopyruvate |
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| Authors: | Issa Yavari Zinatossadat Hossaini Maryam Sabbaghan |
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| Institution: | Department of Chemistry, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran |
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| Abstract: | Isoquinoline reacts with ethyl bromopyruvate in the presence of dialkyl acetylenedicarboxylates or diaryloylacetylenes to produce dialkyl 1-(2-ethoxy-2-oxoacetyl)pyrrolo2,1-a]isoquinoline-2,3-dicarboxylates or ethyl 2-2,3-diaryloylpyrrolo2,1-a]isoquinoline-1-yl]-2-oxoacetates in good yields. |
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| Keywords: | Activated acetylenes Isoquinoline Quinoline Pyridine Indolizine |
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