Asymmetric hydrogenation of tri-substituted alkenes with Ir-NHC-thiazole complexes |
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Authors: | Klas Källström |
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Institution: | Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE-751 23 Uppsala, Sweden |
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Abstract: | An efficient chiral N-heterocyclic carbene ligand for the Ir-catalyzed asymmetric hydrogenation of largely unfunctionalized tri-substituted olefins has been developed. The Ir-NHC-thiazole catalyst is able to reduce a large variety of substrates with excellent conversions and good enantioselectivities with ee’s ranging from 34% to 90%, depending on the geometry around the double bond of the substrates. |
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