First synthesis and determination of the absolute stereochemistry of iso-cladospolide-B and cladospolides-B and C |
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| Authors: | G.V.M. Sharma K. Laxmi Reddy J. Janardhan Reddy |
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| Affiliation: | D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | ![]()
The syntheses of iso-cladospolide-B, cladospolide-B and cladospolide-C are reported with 4S,5S,11S-configuration. Of the three stereogenic centres, the C-4/C-5 vic-diol was created by Evans aldol condensation, while the C-11 stereocentre was created by Jacobsen’s method. The synthesis of cladospolides 1-3 defined the absolute stereochemistry of these natural products. |
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| Keywords: | Aldol condensation vic-Diol Jacobsen&rsquo s method Seco-acid Macrolactonisation |
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