Ethynylation of indoles with 1-benzoyl-2-bromoacetylene on Al2O3 |
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| Authors: | Lyubov&rsquo N. Sobenina,Al&rsquo bina I. Mikhaleva,Alexander M. Vasil&rsquo tsov,Boris A. Trofimov |
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| Affiliation: | a A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russian Federation
b Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, Ont., Canada N9B 3P4 |
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| Abstract: | Indoles are cross-coupled with 1-benzoyl-2-bromoacetylene on Al2O3 at room temperature under base and solvent-free conditions to afford 3-(2-benzoylethynyl)indoles in 22-76% yields, thus representing the first examples of direct ethynylation of the indole nucleus. |
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| Keywords: | Indoles 1-Benzoyl-2-bromoacetylene Alumina 3-(Benzoylethynyl)indoles 2-(Benzoylethynyl)-4,5-dihydrobenz[g]indole |
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