Unusual sulfanylation through ring transformation of arene-tethered 2H-pyran-2-ones by in situ built Michael adduct |
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| Authors: | Diptesh Sil Rishi Kumar Vishnu Ji Ram |
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| Institution: | a Divisions of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226 001, India
b Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India |
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| Abstract: | A novel synthesis of highly functionalized alkylsulfanylmethyl arenes 8a-m through the ring transformation of 6-aryl-4-methyl/ethylsulfanyl-2H-pyran-2-one-3-carbonitriles 1a-j, by reaction with methyl vinyl ketone 2, is delineated and illustrated. To ascertain the course of reaction, 3-arylsulfanylmethyl-2-methyl-6-methylsulfanyl-4-phenylbenzonitriles 8k-m were also prepared from the reaction of 1 with 4-arylsulfanyl-butan-2-ones 7c,d. |
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| Keywords: | Sulfanylated arenes 2H-Pyran-2-one Ring transformation reactions |
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