Phosphomimetic sulfonamide and sulfonamidoxy analogues of (Lyso)phosphatidic acid |
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| Authors: | Joanna Gajewiak |
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| Institution: | Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108-1257, United States |
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| Abstract: | Lysophosphatidic acid (LPA) and phosphatidic acid (PA) are potent bioactive lipid mediators of signal transduction and are inactivated by phosphatases. To obtain receptor-isoform selective ligands with neutral phosphomimetic head groups, we performed the stereoselective synthesis of LPA and PA analogues with trifluoromethanesulfonamide and trifluoromethanesulfonamidoxy moieties replacing the phosphomonoester. |
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| Keywords: | Stereoselective phospholipid synthesis Aminooxy group Trifluoromethanesulfonamide Trifluoromethanesulfonamidoxy G-protein coupled receptor |
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