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Studies toward the synthesis of salinosporamide A, a potent proteasome inhibitor |
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| Authors: | Virginie Caubert |
| Institution: | Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France |
| Abstract: | An α-methylenepyrrolidinone bearing all the functionalities and relative configurations of an advanced intermediate in the synthesis of salinosporamide A and analogues has been synthesized from methyl pyroglutamate through regio- and stereoselective N-methylnitrone cycloaddition. |
| Keywords: | Protease inhibitor Salinosporamide A Pyroglutamate 1 3-dipolar cycloadditions Diazomethane N-Methylnitrone Samarium diiodide |
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