Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents |
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| Authors: | Nicolas Lebouvier Typhanie Corbin Guillaume Le Baut Marc Le Borgne |
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| Affiliation: | a Department of Pharmacochemistry, BioCiT UPRES EA 1155, Faculty of Pharmacy, Nantes Atlantic University, 1 rue Gaston Veil, F-44035 Nantes, France
b Yang Ji Chemical Co. Ltd, 638-6 Sunggok-Dong, Ansan, 425-110 Kyoungki-do, South Korea |
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| Abstract: | New conazole antifungals, in the series of triazole alcohols 23a-d and 24a-e incorporating an indole moiety substituted at 5-position by halogens, a cyano or 4-methoxyphenyl group, have been synthesized by ring opening of corresponding oxiranes 15 and 16. These dihalogeno intermediates and their congeneers could be prepared in high yields by Corey-Chaykovsky reaction under microwave irradiation. |
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| Keywords: | Corey-Chaykovsky reaction Microwave irradiation Indole Antifungal |
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