Synthesis of isocyanide derivatives of α-aminoalkylphosphonate diphenyl esters |
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Authors: | Marcin Sieńczyk Maciej Kliszczak Józef Oleksyszyn |
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Institution: | Division of Medicinal Chemistry and Microbiology, Chemistry Department, Wroclaw University of Technology, Wybrze?e Wyspiańskiego 27, 50-370 Wroc?aw, Poland |
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Abstract: | This letter describes the first example of the synthesis of isocyanide derivatives of α-aminoalkylphosphonate diphenyl esters. This method produces the title compounds in high purity and in very good yields. It also permits the generation of an α-aminophosphonate-based library of biologically active phosphonopeptides. Preliminary experiments demonstrate their application as substrates for the Ugi-type multicomponent condensation. |
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Keywords: | α-Aminoalkylphosphonates Isocyanides Phosphonopeptides Ugi-type condensation |
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