Formal total syntheses of aspidosperma alkaloids via a novel and general synthetic pathway based on an intramolecular Heck cyclization |
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| Authors: | Pereira Jennifer Barlier Mireille Guillou Catherine |
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| Affiliation: | Institut de Chimie des Substances Naturelles, Bt 27, CNRS Avenue de la Terrasse, 91198 Gif-sur-Yvette, France. |
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| Abstract: | ![]()
Cyclizations of bicyclic amides via an intramolecular Heck reaction followed by an oxidation reaction generate tricyclic spirocyclohexadienones. From these compounds, tetracyclic ketones can be synthesized to provide useful intermediates for the synthesis of indole alkaloids. |
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