Synthesis of new pyrrolo-[3,4-c]isoxazole, pyrrolo[2,3-d]-[1,2,3]triazole, triazolo[4,5-c]-pyridazine, and dipyrrolo-[3,2-b:3′,4′-d]pyran derivatives |
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Authors: | F A Amer M Hammouda A-A S El-Ahl B F Abdel-Wahab |
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Institution: | (1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt;(2) Applied Chemistry Department, National Research Center, Dokki, Giza, Egypt |
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Abstract: | New pyrrolo3,4-c]isoxazole derivatives were synthesized from the key intermediates 4-cyanopyrrolidin-3-ones in two steps.
Pyrrolo2,3-d]1,2,3]triazoles and triazolo4,5-c]pyridazine were obtained from 2-arylhydrazono-4-cyano-1-(4′-methoxyphenyl)-3-oxopyrrolidines
by refluxing with phenylhydrazine in either ethanol or glacial acetic acid. Aldol self-condensation of 1-aryl-4-cyanopyrrolidin-3-ones
afforded dipyrrolo-3,2-b:3′, 4′-d]pyran derivatives.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1841–1848, December, 2007. |
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Keywords: | oxime β -oxo nitriles pyrrolidin-3-ones aldol condensation |
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