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Design and synthesis of novel 1,4-benzodiazepine surrogates as potential CCKA and CCKB antagonists via palladium-catalyzed three-component cascade reactions |
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| Authors: | H Ali Dondas Samet Belveren Samet Poyraz Ronald Grigg Colin Kilner Marcos Ferrándiz-Saperas Elisabet Selva José M Sansano |
| Institution: | 1. Department of Chemistry, Faculty of Pharmacy, Mersin University, 33169, Mersin, Turkey;2. School of Chemistry, Leeds University, Leeds, LS2 9JT, UK;3. Departamento de Química Orgánica, Instituto de Síntesis Orgánica (ISO) and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, Apdo. 99, E-03080, Alicante, Spain |
| Abstract: | Structurally diverse novel 1,4-benzodiazepine analogues related to selective CCKA antagonist MK-329, and CCKB antagonists L-365,260 and YM022 are prepared via palladium-catalyzed three component domino reactions involving allenylation-carbonylation-anion capture in one-pot cascade protocol in good to excellent yields. |
| Keywords: | Benzodiazepines Cholecystokinin (CCK) receptor Palladium Allenylation Carbonylation |
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