Palladium-catalyzed site-selective hydrogen isotope exchange (HIE) reaction of arylsulfonamides using amino acid auxiliary |
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Authors: | Wei Liu Xingyu Xu Hongyan Zhao Xiaoyu Yan |
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Institution: | Department of Chemistry, Renmin University of China, Beijing 100872, China |
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Abstract: | Hydrogen isotope exchange (HIE) is a versatile method for the introduction of deuterium to organic compounds. Herein, regioselective deuteration of sulfonamides is achieved by palladium-Catalyzed HIE reaction. By using amino acid as weakly coordination-directing auxiliary, a variety of sulfonamides are efficiently deuterated at the ortho-position. Placing competing directing groups on the aromatic ring does not affect the site-selectivity. |
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Keywords: | Deuteration Palladium catalysis Sulfonamide C-H activation |
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